Abstract
The tapetum lucidum is a reflective layer that lies beneath part of the retina in the eyes of many animals. It is believed to enhance night vision by reflecting light onto the sensory cells of the retina. Primates, including humans, do not have a tapetum. Routine safety studies have revealed that treatment of Beagle dogs with high doses of azithromycin, a novel macrolide antibiotic, causes changes in the color and reflectivity of the tapetal fundus. In order to determine whether the change is due to a direct effect on the tapetum as opposed to a change in transparency of the retina, a study was conducted that compared the effects of azithromycin treatment in normal versus congenitally atapetal dogs.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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