Abstract
The influence of anterior chamber infusion of atropine (10 μg/ml) on intraocular pressure, outflow facility, rate of aqueous humour formation, and the routes for aqueous humour drainage was studied in anaesthetized cynomolgus monkeys. [ 131 I]Albumin was used to determine the flow of aqueous humour from the atropine-treated eye; [ 125 I]albumin was used in the control eye. Atropine produced no significant changes in “gross” facility of outflow and aqueous humour drainage by vascular routes. It reduced the intraocular pressure 2·0 mmHg and raised the average rate of aqueous humour production from 2·28 to 2·54 μl/min. This rise was probably significant, P < 0·05. The average flow by way of uveo-scleral routes was raised from 0·90 to 1·07 μl/min; this rise was probably significant also, P < 0·05. A small dose of pilocarpine (5 μg/ml) known to have little or no effect on refraction and a variable effect on facility of outflow reduced the rate of uveo-scleral flow. Atropine inhibited this effect probably by preventing a localized contraction of the longitudinal fibres of the ciliary muscle. Autoradiography was used to demonstrate the effect of atropine and pilocarpine on the flow through uveo-scleral routes.
Published Version
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