Abstract
Previous research with ASEA (a saline beverage with stable superoxide complexes) found increased fatty acid mobilization in cyclists after 7 d ingestion. We hypothesized that run time to exhaustion would be favorably influenced by ASEA intake due to enhanced fatty acid oxidation and muscle glycogen sparing. Sixty mice were randomized to 1 of 4 treatment groups (n=15 each): placebo sedentary (PS), ASEA sedentary (AS), placebo run (PR), and ASEA run (AR). Mice were gavaged daily with ASEA or placebo (0.3 ml/d) for 7 d. PR and AR groups were run to exhaustion (24 m/min) at the end of the 7‐d gavage period, with AR running significantly longer than PR (68.0±9.2 vs. 52.8±7.4 min, respectively) (p<0.001). At the point of exhaustion, liver glycogen was undetectable for both AR and PR. When adjusted to run time, the estimated rate of muscle glycogen depletion was different between AR and PR (0.036±0.014 and 0.052±0.018 ug/mg protein per min, respectively, p=0.017). Skeletal muscle phosphorylated acetyl‐CoA carboxylase (p‐ACC) was significantly increased in AR compared to AS (p=0.020) and PR (p=0.045). Fatty acyl CoA transport (CPT1), and beta‐oxidation (beta‐HAD) were not different between AR and PR. ASEA increased run time to exhaustion by 29% in mice, potentially through less inhibition of fatty acid oxidation via increased P‐ACC, and muscle glycogen sparing percent (30%).Funded by Reoxcyn Discoveries Group.
Published Version
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