Effects of Arginine Residue Introduction upon Interaction and Complexation Behavior of Peptide Ribonucleic Acids (PRNAs) with RNA: Synthesis and Properties of -Containing Arginine

Abstract

A novel nucleic acid model using alpha-peptide ribonucleic acid (alpha-PRNA) possessing alternative alpha-PRNA/arginine sequences, where the arginine residue would be expected to stabilize the complex not only by the conventional hydrogen-bonding interactions between the complementary nucleobase pairs but also through the electrostatic interactions between positively charged side-chain groups and RNA's phosphate anions on the backbone. These alpha-PRNA form stable sequence-specific complex with the complementary RNA.