Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate

Abstract

Abstract: Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results: Rat serum essential fatty acid; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid (C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between 8.91 ± 0.53- 11.71 ± 2.55 and 33.71 ± 2.12- 37.11 ± 2.12, respectively. It was determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 ± 1.29- 9.96 ± 1.18 and 14.72 ± 3.66- 22.13 ± 4.82, respectively. Conclusion: In our study, alterations in fatty acid contents were observed, and results suggesting that arbutine affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid amounts. Keywords: Arbutin (ARB), Potassium bromate (KBrO3), Fatty acid (FA), Polyunsaturated fatty acids (PUFA), Monounsaturated fatty acids (MUFA), Wistar Albino Rat.