Abstract
目的 研究舍曲林治疗对老年高血压病患者降压疗效的影响. 方法 老年高血压病患者予以汉密顿抑郁量表(HAMA)和抑郁自评量表(SDS)测定,对量表测定为阳性的病例按随机单盲法分为A、B2组,对量表评定为阴性患者作为C组,均口服硝苯地平,A组病例同时加服舍曲林片.疗程均为12个月. 结果 老年高血压合并抑郁患者在治疗前HAMD、SDS评分差异无显著性,经抗抑郁治疗后HAMD、SDS评分下降有显著差异(P＜0.01).A、B、C 3个组降压有效率分别为91.89%,、65.70%、80.00%.A组加用抗抑郁治疗后,∑ST显著下降,CI和LVEF明显增加,与B组比较有显著差异(P＜0.01). 结论 伴有抑郁情绪的老年高血压患者加用抗抑郁治疗可以改善患者的抑郁情绪,并且增加降压药物的疗效。
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