Abstract

Objective To study the effect of Angong-niuhuang pill on expression ofeNOSmRNA in spontaneously hypertensive rats after intracerebral hemorrhage and to explore it's protective mechanism. Methods 120 spontaneously hypertensive rats were randomly divided into four groups: model group, western medicine treated group. Angong-niuhuang pill treated group, combining traditional Chinese medicine western medicine group, expression ofeNOSmRNA in rat brain tissue was detected by RT-PCR. Results Expression of BCL-2mRNA in combining traditional Chinese medicine western medicine group was significantly higer than other goups(P〈0.01), Compared with model group, the expression of BCL-2mRNA in western medicine treated group and Angong-niuhuang pill treated group was markedly increased (P〈0.01), the differences between Angong-niuhuang pill treated group and Western medicine treated group were not obvious (P〉 0.05). Conclusion Protective effect of Angong-niuhuang pill on spontaneously hypertensive rats after intracerebral hemorrhage is related to the the inducement of eNOS expression. Key words: Angong-niuhuang Pills; Intracerebral hemorrhage; eNOSmRNA

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