Abstract
Methods Twenty one body-builders were studied 14 anabolic steroid users and 7 controls matched for age and training history. First pass CMR perfusion imaging was performed on a 1.5T Avanto (Siemens, Erlangen, Germany) after adenosine-induced hyperemia (140 mcg/kg/min) and at rest using a hybrid echo-planar imaging sequence. Images of the base, mid-ventricle and apex were acquired and the myocardium was divided into 16 segments as well as endocardial and epicardial layers. After image registration, a modified Fermi-constrained deconvolution algorithm was applied pixel-wise to quantify absolute MBF. Late gadolinium enhancement (LGE) imaging was performed as well as standard assessment of ventricular volumes, function and LV mass. Data were analysed using a linear mixed effects model.
Highlights
Anabolic steroids are known to induce left ventricular hypertrophy (LVH)
There was a significant interaction effect with steroid use and the layer examined such that the difference in endocardial myocardial blood flow (MBF) between the steroid users and non-users, and the differences between the groups in epicardial MBF was 6.89 ml/100g/min higher
Resting differences in MBF due to steroid use persisted after adjusting for wall thickness (b = 1.84, 95% CI 0.43 to 3.26, p=0.011 for wall thickness) but were abolished by vasodilator stress
Summary
Effects of anabolic steroid use on myocardial perfusion in body-builders: a quantitative cardiovascular magnetic resonance Study. Tevfik F Ismail1*, Li-Yueh Hsu, Peter J Angell, Andrew Jabbour, Anders M Greve, Carla Gonçalves, Ankur Gulati, Benjamin Hewins, Gillian Smith, Rick Wage, Annette L Dahl, Michael Roughton, Gregory Whyte , Keith George, Dudley J Pennell, Andrew E Arai, Sanjay K Prasad. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. From 16th Annual SCMR Scientific Sessions San Francisco, CA, USA. 31 January - 3 February 2013
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