Effects of an early and low-dose hypolipidemic treatment of atherosclerosis: An OCT study in watanabe rabbits

Abstract

TC Ezetimibe 224.3 (34.5) 193.3 (23.8) -12.8 (10.9)** <.001 <.001 Lomitapide 230.8 (43.5) 176.3 (43.9) -22.1 (12.8)** 0.04 0.02 Combination 225.9 (30.4) 149.8 (41.9) -32.8 (17.7)** <.001 LDL-C Ezetimibe 146.5 (27.7) 116.8 (17.6) -18.8 (12.9)** <.001 <.001 Lomitapide 150. 9 (32.9) 103.3 (31.7) -30.0 (14.2)** <0.05 0.01 Combination 149.6 (23.7) 82.2 (34.5) -43.9 (23.4)** <.001 LDL1-C Ezetimibe 30.7 (11.2) 22.4 (8.6) -24.0 (23.4)** 0.01 0.004 Lomitapide 31.3 (15.3) 21.8 (14.5) -28.3 (33.4)* 0.64 0.02 Combination 30.9 (13.5) 14.2 (8.9) -49.7 (31.4)** 0.004 LDL2-C Ezetimibe 32.1 (16.4) 26.1 (12.7) -11.4 (34.7)* 0.04 0.01 Lomitapide 30.5 (12.6) 20.4 (10.3) -28.8 (46.0)* 0.15 0.33 Combination 33.5 (13.8) 16.4 (8.8) -40.6 (35.0)** 0.01 LDL3-C Ezetimibe 41.0 (13.8) 34.8 (14.6) -14.0 (27.5)* 0.006 0.003 Lomitapide 41.0 (12.9) 23.0 (12.2) -40.0 (30.4)* 0.01 0.78 Combination 42.2 (13.5) 22.7 (15.2) -42.9 (38.5)* 0.003 LDL4-C Ezetimibe 9.5 (7.0) 8.3 (7.2) -13.3 (48.0) 0.90 0.71 Lomitapide 10.8 (10.0) 6.2 (4.0) -20.6 (45.7) 0.69 0.95 Combination 11.1 (8.7) 5.9 (3.5) -19.5 (70.2)* 0.71 Non HDL-C Ezetimibe 174.5 (31.3) 140.0 (18.9) -18.4 (12.3)** <.001 <.001 Lomitapide 180.9 (35.3) 130.0 (35.5) -26.2 (15.5)** 0.14 0.01 Combination 176.0 (25.2) 104.5 (39.8) -40.0 (21.4)** <.001 ApoB Ezetimibe 112.6 (16.1) 93.8 (11.5) -16.0 (10.1)** <.001 <.001 Lomitapide 116.8 (18.2) 88.0 (19.3) -22.9 (14.3)** 0.15 0.03 Combination 114.4 (18.0) 75.0 (22.6) -33.9 (19.7)** <.001 ApoB/AI Ezetimibe 0.75 (0.13) 0.62 (0.11) -18.0 (8.2)** 0.02 0.01 Lomitapide 0.77 (0.11) 0.63 (0.13) -17.2 (14.8)** 0.86 0.02 Combination 0.77 (0.11) 0.55 (0.16) -28.8 (19.3)** 0.01 TC/HDL-C Ezetimibe 4.60 (0.82) 3.72 (0.61) -18.5 (8.1)** 0.008 0.42 Lomitapide 4.71 (0.75) 3.92 (0.83) -15.1 (13.8)** 0.42 0.004 Combination 4.65 (0.72) 3.39 (0.95) -27.9 (16.9)** 0.02 ApoB/NonHDL-C Ezetimibe 0.65 (0.04) 0.67 (0.04) 3.6 (5.6)* 0.001 <.001 Lomitapide 0.65 (0.04) 0.69 (0.07) 5.1 (7.1)* 0.57 0.005 Combination 0.65 (0.04) 0.74 (0.09) 12.9 (12.1)** <.001