Abstract
The bizarre, stereotyped behavior observed after the administration of amphetamines to several mammalian species has been attributed to an increase of dopamine (DA) at its receptors due to an increased release or an inhibition of reuptake of DA in dopaminergic terminals of the basal ganglia and portions of the limbic system. The dextrorotatory isomer appears to be at least two and possibly four-to-six-times more potent than levoamphetamine in vivo with respect to the development of stereotyped behavior in the rat and this difference in potency remains unexplained. The chapter discusses a study to examine the effects of amphetamines on the metabolism of catecholamines in the rat brain.
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