Abstract
Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.
Highlights
Natural products have a very special place in drug research and development
The present research work was aimed at the evaluation of cardiovascular changes in diabetic rats treated with methanolic leaf extracts from Aegle marmelos
The methanolic leaf extract was used for further evaluation of biochemical changes in alloxan induced diabetes
Summary
Plants as a source of therapeutically useful drugs have been proved the evidence of high economic importance. Search for new drugs from various plant sources occurs throughout the globe. In India though there are certain limitations or challenges in the resources, standardization of medicinal plants has gained significance in the recent times [1]. Aegle marmelos (L.) Correa is a widely found medicinal plant in India and South Asia. It is being commonly used for its therapeutic properties [2]. The present research work was aimed at the evaluation of cardiovascular changes in diabetic rats treated with methanolic leaf extracts from Aegle marmelos. Ravi Babu Birudu et al.: Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats
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