Abstract
The effects of intravenous amino acids on maximal renal tubular reabsorption of glucose were studied in dogs by clearance techniques. L-Lysine, glycine, and L-alanine caused a significant depression of glucose reabsorption whereas L-aspartic acid and L-leucine did not. These results support other evidence that there is a relationship between the transport mechanisms for a variety of substances such as simple sugars, amino acids, and phosphate in the kidney. The effects, however, are probably not competitive but may depend on some indirect action on net transport such as altered membrane permeability or intracellular osmotic pressure. Incidentally, it was noted that L-aspartic acid, L-lysine, glycine, and L-alanine infused along with glucose resulted in significantly less elevation in plasma glucose concentration than that observed when the same amount of glucose was infused alone. The effects of amino acids on plasma glucose confirm earlier reports that mixtures of amino acids depress elevated blood sugar levels. These effects were found to occur with basic, acidic, and neutral amino acids. The method of action of amino acids in influencing plasma glucose has not been determined, but it may be similar to known effects of leucine, which is thought to induce hypoglycemia, particularly in sensitive individuals, by increasing insulin output.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call