Abstract
Exposure to high amounts of ionizing radiation results in damage to the hematopoietic system characterized by the destruction of hematopoietic cells in bone marrow, thus reducing the production of blood cells. Infections and bleeding that result can be fatal. Aged garlic extract (AGE) has been demonstrated to possess several physiological activities in experimental animals thus, the present study aimed to evaluate the effect of AGE on the hematopoietic syndrome post whole-body exposure to ionizing radiations. Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E + Alpha Lipoic Acid. Blood samples were collected the 8 th day post irradiation to investigate blood picture. Exposure of rats to gamma radiation caused a significant disturbance in the level of white blood cells count (WBCS), Lymphocytes (LY), mid-size population of monocytes, basophils, eosinophils, blasts, and other immature cells (MID),Granulocytes (GR), red blood cells count (RBCs), hemoglobin content (Hb), Mean Corpuscular Volume (MCV), hematocrit value (HTC), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelets count (PLT). In rats exposed to radiation then treated with AGE, the results showed an improvement in all previous parameters. The results of the present investigation showed that AGE intake confers radiation protection to rat’s blood cells parameters after whole-body exposure to ionizing radiation.
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