Abstract
OBJECTIVE: To investigate the effects of different periods of aerobic exercise intervention on hippocampal TGF-β1 expression and spatial learning and memory ability in depressive model rats. METHODS: 36 male SPF grade Sprague Dawley (SD) rats were randomly allocated into 4 groups (n=9) :Control group (C group), Pre-model exercise group (EC group), Model group (M group), Motion group(ce group). Except for group C, all other groups used CUMS stress stimulation to establish an animal model. Morris water maze test was used to detect spatial learning and memory ability of rats. Nissl staining was used to observe the morphology of rat hippocampal neurons. Real-time PCR, Western Blotting were used to detect the expression of TGF-β1. RESULTS: There was no significant difference in time-consumption of escaping the incubation period between the 1st and the 2nd day in each group (P > 0.05). On the fourth day, the escape latency of M group was significantly longer than that of rats in the C and ce groups (P < 0.05). On the 5th day, the escape latency in M group was significantly longer than that in C and ce groups (P < 0.05), and EC group was significantly longer than that in C group (P < 0.05). Results of the number of crossing platforms: The number of crossing in the M and EC groups were significantly lower than those in the C and ce groups (P < 0.01). Compared with EC and M group, the morphological structure of neurons in ce group was better.The expression of TGF-β1 mRNA in hippocampus of EC and ce group was significantly lower than that of C and M groups (P < 0.01). The expression levels of TGF-β1 protein in C and M groups were significantly higher than those in ce group (P < 0.01). The expression of TGF-β1 protein in M rats was significantly higher than that in EC and ce groups (P < 0.01). CONCLUSION: Aerobic exercise intervention can improve the morphological structure of hippocampal CA3 neurons, and decrease the expression of TGF-β1. It indicated that aerobic exercise can improve the depression.
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