Abstract
Currently it is thought that the biosynthesis of glycerolipids is initiated by the acylation of glycerol phosphate or dihydroxyacetone phosphate. The relative contributions of these two metabolic routes are not fully established (reviewed in [I]). There is believed to be a peroxisomal dihydroxyacetone phosphate acyltransferase (DHAPAT) activity in liver [2,3] although on subcellular fractionation DHAPAT activity is also found in mitochondria and microsomes. Glycerol phosphate acyltransferase (GPAT) activity is found in both mitochondrial and microsomal fractions (reviewed in [4]). We have shown that mitochondrial GPAT activity is decreased by adrenalectomy in both fed and fasted animals [5]. Microsomal GPAT activity was decreased by adrenalectomy in fasted animals only [S]. These results show the effects of adrenalectomy and cortisol injection on hepatic DHAPAT activity.
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