Abstract
Aculeacin A1and papulacandin B2are closely related antimycotic agents that interfere with the synthesis of alkalai-insoluble β 1-3 glucan in the cell wall ofCandida albicans, Saccharomyces cerevisiaeandGeotrichum lactis. The chemical structures of both agents contain a long-chain fatty acid, and both agents are strongly inhibitory toC. albicansand some other fungi while having negligible activity against bacteria or protozoa. Earlier studies involving light microscopy of aculeacin A treated cells revealed rounded, distorted cells aggregated in clumps. The sole TEM micrograph of aculeacin A treated cells showed invaginations and globular bodies associated with plasma membranes.
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