Abstract
Background: Hypertension is one of the leading cause of morbidity and mortality in all over the world as in developed and under developing countries. Hypertension mostly associated with other clinical chronic disorders like diabetes mellitus, hyperuricemia, dyslipidemia etc. The ACE inhibitors are a kind of antihypertensive drug that is widely using all over the world. ACE inhibitors lowers blood pressure, but also lower uric acid levels as well.
 Aims & Objectives: To evaluate the efficacy of ACE inhibitors alone and along with the folic acid on systolic & diastolic blood pressure & on serum uric acid level.
 Methodology: This case-control research was carried out at the Medicine Department with the help of the Department of Biochemistry at LUMHS Jamshoro and the PAQSJ Medical Institute in Gambat. A total of 200 mild to moderate hypertension individuals with hyperuricemia were chosen. They were divided into two groups: the control group was taken 10 mg of lisinopril, while the case study group received 10 mg of lisinopril with 0.8 mg of folic acid for 10 to 12 weeks.
 Results: The mean value of systolic B.P in control group after treatment was126 ± 4.9 (P<0.05) while in case study group after treatment was 118 ± 6.12 mmHg (P<0.05). Diastolic B.P in control group after treatment was 90 ± 4.76 mmHg while in case study group was 82.3 ± 3.66 mmHg (P<0.05). The serum uric acid level after treatment in control group was 6.7 ± 4.78 mg/dl while in case study group, it was 5.5 ± 5.11 mg/dl (P<0.001). Serum Folic acid levels after the treatment in control group was 12.31 ± 2.89 while in case study group it was 27.09 ± 3.47 nmol/L (P<0.001). 
 Conclusion: Folic acid enhances the effectiveness of an ACE inhibitor (lisinopril) and has a substantial influence in the lowering of serum uric acid as therapeutic agent in the cases of mild to moderate hypertension associated with hyperuricemia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
