The relationship of serum uric acid and urinary microalbumin with the progression and cognitive dysfunction of patients with Parkinson's disease

Abstract

Objective To study the relationship of the levels of serum uric acid and urinary microalbumin with the progression and cognitive dysfunction of patients with Parkinson' s disease (PD).Methods A retrospective analysis of 102 confirmed cases of PD (including both outpatients and inpatients of our hospital from January 2007 to April 2014) was carried out.102 patients were divided into early-onset group and late-onset group according to patients' ages at onset,PD with cognitive dysfunction group and PD without cognitive dysfunction group according to the assessment of patients' cognitive dysfunction,Ⅰ stage,Ⅱ stage,Ⅲ stage,Ⅳ stage,Ⅴ stage according to the assessment of patients' motor dysfunction (Ⅰ-Ⅱ stage for early stage,Ⅲ stage for mid-stage,Ⅳ-Ⅴ stage for advanced stage).Besides,102 healthy people who had physical examinations in our hospital were recruited as control group.The levels of serum uric acid and urinary microalbumin were detected,statistically analyzed and compared among sub groups.Results The level of serum uric acid of PD group was significantly lower than that of control group (P ＜ 0.01).There was no statistically significant difference in serum uric acid between early-onset group and late-onset group (P ＞ 0.05).The level of serum uric acid of PD with cognitive dysfunction group was lower than that of PD without cognitive dysfunction group (P ＜ 0.05).There were no statistically significant differences in serum uric acid among early stage,mid-stage,advanced stage (P ＞ 0.05).The levels of serum uric acid of each sub group were all lower than that of control group.There were no statistically significant differences in the level of urinary microalbumin between each sub group and control group (P ＞ 0.05).Conclusions The level of serum uric acid in patients with Parkinson' s disease is lower than that of healthy subjects,and low serum uric acid level may be one of risk factors for Parkinson's disease.There is no significant correlation between low serum uric acid level in Parkinson's disease and the disease progression.However,low uric acid level seems to have something to do with the cognitive impairment in patients with PD.There is no significant correlation between urinary microalbumin and the occurrence and development of Parkinson's disease.Appropriate intervention on blood uric acid level may not only help to improve PD patients' quality of life,but also save their medical expenses. Key words: Parkinson's disease; Uric acid; Urinary microalbumin