Abstract
ObjectiveThe goal of this study was to evaluate the in vivo effects of a novel mouthwash on enamel remineralization.Materials and MethodsTen healthy volunteers wore removable intra-oral appliances for three study arms with duration of 5 days each. In 1 study arm, subjects used Oral Essentials Sensitivity FormulaR mouthwash; in another arm they used SensodyneR mouthwash, and in the third arm they used no mouthwash at all. Sequence of mouthwash use was randomized, and study participants and researchers were blinded throughout the study. Subjects used Crest Total CareR toothpaste throughout the study. During a one week washout period before study begin and between each study arm, subjects also used Crest Total CareR toothpaste. A total of 300 enamel samples were included in this study, 150 served as baseline controls, and 150 as test samples subjected to demineralization prior to intra-oral wear. At the end of each study arm, enamel chips were removed from the appliance and underwent standard Microhardness (Knoop) measurements, as did the control samples. Enamel microhardness in the test vs the 2 control groups was compared using the Kruskal-Wallis one-way analysis of variance with post-hoc Tukey’s test to test for differences in remineralization between the 3 treatments.ResultsBoth mouthwashes demonstrated similar levels of recovery from demineralization as the “no mouthwash” arm of the study, with no significant differences for all groupings and comparisons (p>0.05).ConclusionA novel mouthwash for sensitive teeth supports enamel recovery from demineralization.
Highlights
Based on a variety of factors such as saliva composition and production rate, intake of food and drinks, and oral biofilm composition, the pH on the tooth surface is in constant flux throughout the day
Prior to actual tissue loss, surface remineralization can occur through the replacement of lost mineral ions, typically from the salivary reservoir of calcium and phosphate ions, and the dental biofilm may harbor mineral ions that play a role in this process [3,4,5,6,7,8,9,10,11]
All tooth samples underwent statistically similar levels of deand remineralization, softening by a mean 27.24% (S.D. 4.8%) due to demineralization and hardening again after 5 days of intra-oral wear to approximately the pre-demineralization level (p>0.05) and demonstrating no significant differences for all groupings and comparisons.no significant differences were determined between the levels of re-hardening after use of either of the mouthwashes or no mouthwash at all (p>0.05)
Summary
Based on a variety of factors such as saliva composition and production rate, intake of food and drinks, and oral biofilm composition, the pH on the tooth surface is in constant flux throughout the day. The enamel surface is directly affected by these pH levels, with the tooth surface undergoing closely linked cycles of deand remineralization. The reduced enamel surface hardness that results from demineralization [1,2,3] is paralleled by a heightened risk of abrasion and attrition [4,5,6]. Variables that affect the rate of demineralization include the pH and duration of the acid challenge [3,4,5,7,8,9]. Mouthwashes and toothpastes can be helpful in supporting dental recovery by promoting remineralization after acid attack [12,13,14]
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