Abstract
The effect of a potent LHRH analog (ICI 118,630) on the growth of the estrogen-induced transplantable PRL-secreting rat pituitary tumor 7315a was compared with the effect of the antiestrogen tamoxifen. Implantation of this PRL-secreting tumor induced hyperprolactinemia, and plasma FSH and LH levels were suppressed. The total PRL content of the pituitary gland was decreased, but the glands of tumor-bearing animals contained 50–100% more FSH and LH than nontumor-bearing controls. Plasma 17β-estradiol concentrations and ovarian weight were not changed, but uterine weight decreased after tumor implantation. The administration of the LHRH analog (5 or 25 μg, sc, twice daily for 12 days) inhibited pituitary tumor growth by 68 ± 11% and 71 ± 8%, respectively (P < 0.01 and P < 0.01, respectively). This was accompanied by a decrease in plasma 17β-estradiol and the ovarian and uterine weights. The total FSH and LH contents of the pituitary glands of the LHRH-treated tumor-bearing rats were diminished in the presenc...
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