Abstract
GnRH-a-Induced Perimenopausal Rat Modeling and Black Cohosh Preparations' Effect on Rat's Reproductive Endocrine.
Highlights
Endometriosis, EMS for short, means that functional endometrial glands or stromata are ectopic outside the uterine cavity, which mainly occurs in female genitalia, peritoneum, bladder and rectum
The animal model successfully achieved a significant decrease in the E2, follicle stimulating hormone (FSH), and luteinizing hormone (LH) levels in rats, and could cause the rats to have rising body surface temperature similar to hot flashes in the perimenopausal period
The intervention with E2 and isopropanolic extract of cimicifuga racemosa (ICR) could effectively relieve such “perimenopausal symptoms”, and ICR had no obvious effect on the serum sex hormone level in rats
Summary
Endometriosis, EMS for short, means that functional endometrial glands or stromata are ectopic outside the uterine cavity, which mainly occurs in female genitalia, peritoneum, bladder and rectum. It is a common gynecological benign disease, which occurs in about 10%-15% of women of childbearing age [1], and the incidence rate has obviously increased in recent years [2]. EMS has a wide range of pathological changes and forms It is a benign lesion, but has malignant biological behavior such as infiltration, metastasis, and recurrence [4]. Some studies have preliminarily confirmed that black cohosh preparations can antagonize perimenopausal symptoms of EMS patients treated with GnRH-a after operation
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