Abstract
Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) = 503 +/- 439] nor the TAG oil PPTG on a chronic DAG diet (AUC = 517 +/- 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC = 565 +/- 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels.
Highlights
Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs)
Recent interest relevant to this issue has focused on 1,3-DAG oil as such a diet alternative
In very recent studies by our group, we did not observe reduced entry of chylomicrons into the circulation of normal C57BL/6J mice gavaged with DAG compared with TAG [46]
Summary
Participants were recruited from the Columbia University Medical Center (CUMC) community and surrounding neighborhood by means of Institutional Review Board-approved flyers. Potential candidates were screened via telephone and asked to come to the General Clinical Research Center (GCRC) at CUMC for further evaluation of their eligibility. After obtaining signed informed consent, a study investigator obtained a medical history, performed a physical examination, and drew fasting blood. Eligible participants visited the GCRC for an enrollment visit, during which they read and signed a second informed consent form for the study protocol. Participants met with a registered dietitian, who provided nutritional counseling on diet requirements and study food consumption. They were given an opportunity to taste study foods, and preferences were noted. The study was approved by the Institutional Review Board of the CUMC
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