Abstract
Previous experiments indicated that drug treatments which increase serotonergic activity produce dose-related reductions in sucrose sham feeding. In the present studies, 5-hydroxytryptamine (5-HT, 2 mg/kg, IP) significantly reduced sham feeding; its effect was reversed by the peripheral 5-HT receptor antagonist, xylamidine (3 mg/kg, IP). At the same dose, 5-HT did not affect water sham drinking. These are the first data to implicate serotonergic activity at peripherally located 5-HT receptors in the modulation of sucrose sham feeding. d- Fenfluramine (3 mg/kg, IP) also reduced sham feeding, an effect that was weakly attenuated by xylamidine, suggesting substantial mediation of its effect by centrally located 5-HT receptors. Sham drinking was reduced by d- fenfluramine (3 mg/kg), although to a lesser degree. In comparison with the previous studies, the present data suggest that in smaller doses d- fenfluramine is relatively selective in its effect on sham feeding, but that, in larger doses, the selectivity may be lost.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
