Similar effect of raclopride and reduced sucrose concentration on the microstructure of sucrose sham feeding

Abstract

Raclopride, a dopamine D 2 antagonist, decreases the intake of sucrose solutions during sham feeding tests and of water during sham drinking tests in rats. To determine whether the reduced intake of sucrose by raclopride was due to a decrease in the positive reinforcing effect of sucrose or to an impairment in licking movements, we compared the rate, efficiency and pattern of licking after two procedures each of which decreased sucrose sham intake about 50%; these were (a) pretreatment with raclopride (ID 50), and (b) dilution of the sucrose concentration sham fed from 10 to 5%. Microstructural analysis failed to reveal significant differences in the rate, efficiency (licks/ml) or patterns of licking between these two procedures. When raclopride inhibited the sham drinking of water, the rate and efficiency of licking were normal, but the patterns of licking were qualitatively different from those observed when raclopride inhibited the sham feeding of sucrose. We conclude that raclopride decreases intake of 10% sucrose during sham feeding and intake of water during sham drinking by decreasing the positive reinforcing potency of the orosensory effect(s) of the two liquids on licking rather than by decreasing the ability to lick. These results provide strong evidence that interaction of dopamine at D 2 receptors is necessary for the normal sensory and/or hedonic processing of the orosensory stimuli produced by sucrose during sham feeding and by water during sham drinking.