Effectivity of a fluoride varnish with silver nanoparticles for enamel remineralisation in patients with trisomy 21

Abstract

Event Abstract Back to Event Effectivity of a fluoride varnish with silver nanoparticles for enamel remineralisation in patients with trisomy 21 America S. Mares-Garcia1, Claudia Butron-Tellez2, Mauricio Pierdant-Perez1, Jairo Mariel-Cardenas1, Gabriela Moreno-Meraz2, Jose L. Ramirez-Garcia-Luna2 and Antonio A. Gordillo-Moscoso1 1 Universidad Autonoma de San Luis Potosí, Faculty of MEDICINE, Mexico 2 Universidad Autonoma de San Luis Potosí, Faculty of Stomatology, Mexico Children with trisomy 21 exhibit oral health abnormalities that confer higher risk for caries development. Fluorinated varnishes have been used as a preventive method for this pathology, and in the treatment of dental lesions with white spots, considered the first stage of these lesions. Silver nanoparticles have demonstrated to exert a bactericidal effect against oral pathogens, without pigmentation of the dental enamel and with no evidence of toxicity. To assess the affectivity of the combination of these strategies, a randomized controlled double-blind trial with a split-plot design was performed in 22 children with white spots on both maxillary dental teeth. One tooth received three applications of a fluoride varnish with silver nanoparticles, and the other one, three applications of the same varnish without nanoparticles. We measured the mineral content of the teeth with a laser cavity detection pen after the first application of the varnishes, and 3 months after the last application to assess the degree of mineralization of the tissue. We found significant differences between teeth treated with and without silver nanoparticles; teeth treated with the varnish with silver nanoparticles appeared to be more mineralised. Treatment with a fluoride varnish with silver nanoparticles is more effective to promote dental remineralisation of teeth affected with white spot lesions in children with trisomy 21. This strategy may be used as a prophylactic measure to avoid development of caries and to improve oral health in this population.