Abstract
The standard of care for the treatment of ocular surface lesions seems to have changed from surgery to topical chemotherapeutic agents as supplements to it or even as sole therapy, despite the scarcity of long-term studies in the published literature. A search in the academic search engines of PubMed, Google academic and Cochrene, of articles published in English language from the years 1997 to 2020 on chemotherapeutic management of ocular surface diseases.
Highlights
The standard of care for the treatment of ocular surface lesions seems to have changed from surgery to topical chemotherapeutic agents as supplements to it or even as sole therapy, despite the scarcity of long-term studies in the published literature
Topical or perilesional chemotherapy as a single therapeutic agent has proven to be an effective treatment avoiding the risks of repeated surgical interventions
Treatment strategies are affected by tumor staging according to the American Joint Cancer Committee (AJCC) T-stage at presentation [1,2], so any suspicious lesion requires a histopathological diagnosis currently assisted by imaging studies such as anterior segment optical coherence tomography (AS-OCT) [3-5]
Summary
The standard of care for the treatment of ocular surface lesions seems to have changed from surgery to topical chemotherapeutic agents as supplements to it or even as sole therapy, despite the scarcity of long-term studies in the published literature. Topical chemotherapy is becoming the preferred approach in treating ocular surface lesions, especially for diffuse, annular, or multifocal lesions which are difficult to manage surgically. Ocular surface neoplasms can present as a pigmented or non-pigmented lesion of the conjunctiva or cornea, usually near the limbus. Ocular surface squamous neoplasms (OSSN) can be diagnosed clinically by their gelatinous, papillary, or leukoplastic appearance. They often spread as a cell growth on the cornea. Treatment strategies are affected by tumor staging according to the American Joint Cancer Committee (AJCC) T-stage at presentation [1,2], so any suspicious lesion requires a histopathological diagnosis currently assisted by imaging studies such as anterior segment optical coherence tomography (AS-OCT) [3-5]
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