Effectiveness of systemic ozone therapy for the correction of endotoxin aggression in children with generalized appendicular peritonitis

Abstract

The aim: to study the effectiveness of the use of systemic ozone therapy according to the method developed by us in the complex treatment of children with generalized appendicular peritonitis at the stage of postoperative treatment in relation to the correction of indicators of endotoxin aggression. Materials and methods. On the basis of the Clinic of Pediatric Surgery of the Children’s Republican Clinical Hospital (Donetsk) 60 school-age children (from 7 to 17 years old), operated on for generalized appendicular peritonitis, were examined. The group 1 consists of 30 children, who at the stage of the postoperative period in addition to comprehensive therapy received a course of systemic ozone therapy developed by us. 30 patients of the group 2 received the traditional treatment. In all children the initial level of systemic endotoxemia indicators was determined. Blood sampling from patients was carried out initially before surgery. The dynamics of the studied indicators were evaluated on the 7th and 14th days of the postoperative period. Results. In all patients with generalized appendicular peritonitis the development of endotoxin aggression was established. Against the background of a course of systemic ozone therapy by the 14th day of the postoperative period, a statistically significant (p < 0.05) decrease in the level of indicators of endotoxin aggression relative to patients of the comparison group was noted. Conclusions. The results obtained prove that the development of widespread appendicular peritonitis occurs in children with the formation of endotoxin aggression. The use of systemic ozone therapy according to our proposed method in the complex therapy of these patients at the stage of the postoperative period makes it possible to achieve a reduction in laboratory indicators of endotoxin aggression in a shorter time.