Evaluation of the effectiveness of ozone therapy in the early postoperative period in children with appendicular peritonitis

Abstract

The article examines the effectiveness of the use of ozone therapy in the complex treatment of children with appendicular peritonitis at the stage of the early postoperative period in relation to the correction of laboratory indicators of endotoxin aggression and relief of the main clinical symptoms. 60 children operated on for widespread appendicular peritonitis were examined. The main group consisted of 30 children who received a course of ozone therapy in addition to standard complex therapy at the stage of the early postoperative period. Only standard therapy was performed in patients of the comparison group. The control group consisted of 30 healthy children of the same age. Among the patients of the control group, in most cases, its physiological level was established - in 93.3%. The average value of lipopolysaccharides in the group was 0.6±0.1 EU/ml. In turn, among the patients of the main group and the comparison group, all children (100%) showed the development of endotoxin aggression. So, in the main group, the initial average value of lipolysaccharides was 2.6 ± 0.2 EU/ml, and in the comparison group - 2.50.2 EU/ml. 2 weeks after the surgical intervention in patients of the main group, the increased level of lipolysaccharides remained only in 20.0% of children. At the same time, the average value of the indicator was 0.8±0.1 EU/ml. Among the patients of the comparison group, on the 14th day of the postoperative period, 50.0% of children retained an elevated level of lipopolysaccharides, and the average value of the indicator was 1.50.1 EU/ml. It is proved that the use of ozone therapy according to the proposed method at the stage of the early postoperative period in the complex treatment of children with widespread appendicular peritonitis makes it possible to reduce laboratory indicators of endotoxin aggression in a shorter time and accelerate the regression of clinical symptoms.