Effectiveness of Surface Treatment with Amine Plasma for Improving the Biocompatibility of Maxillofacial Plates

Yeon-Woo Jeong,Hong-Ju Park,Seunggon Jung,Rok Young Kim,Jeong Joon Han,Byung-Hoon Kim,Min-Suk Kook

doi:10.3390/ma12162581

Yeon-Woo Jeong, Hong-Ju Park + Show 5 more

Open Access

https://doi.org/10.3390/ma12162581

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Journal: Materials	Publication Date: Aug 13, 2019
Citations: 10	License type: CC BY 4.0

Affiliation: Chonnam National University, Chosun University

Abstract

To date, no products have been presented for the surface treatment of metal plates used for repairing maxillofacial defects caused by trauma. Plasma surface treatment is a useful technique for chemically modifying the surfaces of biomaterials. Amine plasma-polymerization is an efficient way to prepare bioactive thin film polymers terminated with nitrogen-containing functional groups. The purpose of this study was to investigate the improvement in biocompatibility of titanium (Ti) plates treated with amine plasma-polymerization, and analyze their surfaces characteristics. To compare biocompatibility levels, in vitro test and animal study were performed using an amine plasma-polymerized Ti plate and an untreated Ti plate. After amine plasma-polymerization, the hydrophilicity of the Ti surface was remarkably improved. Biocompatibility was also improved for the Ti plates treated with amine plasma. The clinical application of this technique will not only shorten the time required for osseointegration, but will also improve the regeneration of bone.

Highlights

In the oral and maxillofacial region, various trauma-related bone defects can occur
The purpose of this study was to investigate the improvement in biocompatibility of titanium plasma-polymerization technique applied to titanium plate surface coating
These results suggest that amine plasma treatment on titanium plate may increase biocompatibility and osteogenesis

Summary

Introduction

In the oral and maxillofacial region, various trauma-related bone defects can occur. various efforts have been made to develop treatments for bone defect recovery and reconstruction. [1,2,3,4].For the reconstruction of bone defects, various bone graft materials and bone substitutes are used in combination with frequent applications of metal plate fixation [5,6,7,8,9]. In the oral and maxillofacial region, various trauma-related bone defects can occur. Various efforts have been made to develop treatments for bone defect recovery and reconstruction. For the reconstruction of bone defects, various bone graft materials and bone substitutes are used in combination with frequent applications of metal plate fixation [5,6,7,8,9]. In the case of the maxillofacial titanium plates used in bone defect site(s), the characteristics of plate surfaces may determine initial osseointegration. If the surface roughness of a plate is non-uniform, it may lead to extended time for osseointegration or failure of osseointegration. Various surface treatments can be used to modify the physical properties of titanium surfaces, such as titanium plasma spraying, hydroxyapatite coating, sandblasted with large acid-etched grits (SLA), and resorbable blast media [10,11,12,13,14,15]

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