Abstract
Background : M itotic count is the most commonly used method of assessing the proliferative activity of a tumor. It is used for classification, grading, prognostication of tumors and sometimes as a decision factor for treatment. Many variables related to procedure or person can influence the mitotic count. This study is designed to find out the effectiveness of special training in mitotic counting in achieving reproducible results. Methods : Sections from twenty cases of carcinoma breast formed the study material. Five junior residents were given the same twenty sections counted by the principal investigator for mitosis counting and original counts were recorded. Then they were instructed regarding mitotic figures using written material and graphic representations. All of them were asked to count the mitotic figures in the same section once again. The results of the two sets were compared. Paired t test and linear regression were the statistical tests used in analysis. Data storage and Analysis is done with EPIINFO software. Results: The mean standard mitotic counts obtained by principal investigator were 8.21. The mean original mitotic count obtained by residents was 15.79. After attending the training program the mean mitotic counts obtained by residents dramatically came close to that obtained by principal investigator ( 8.43 ) Conclusion : In trained hands, the mitotic counts are fairly reproducible and give results comparable to more sophisticated methods of determining proliferative activity in breast cancer. DOI: 10.21276/apalm.2017.999
Highlights
Worldwide breast cancer remains the most common cancer diagnosed in women Approximately 1.8 million new cases are diagnosed per year and incidence is rising by every year.[1]
Mitotic counts, which assess the proliferative activity of the neoplastic tissue is one of the three factors measured by this grading system
There was one (5%) grade 1 and two (10%) grade 3 tumors .When sections from twenty cases of carcinoma of breast were analyzed for mitotic counts, the mean counts obtained by principal observer was 8.21
Summary
Worldwide breast cancer remains the most common cancer diagnosed in women Approximately 1.8 million new cases are diagnosed per year and incidence is rising by every year.[1] After the introduction of mammographic screening large numbers of early stage cancers have been detected and therapeutic options for primary breast cancer has changed significantly It is the duty of the pathologist to provide the clinicians accurate prognostic information for selection of the optimum therapy for each patient. Mitotic counting is the old and classic method used to assess the proliferative activity of normal and neoplastic tissues. It is done by counting mitotic figures in H& E sections. This study is designed to find out the effectiveness of special training in mitotic counting in achieving reproducible results
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