Effectiveness of red propolis and Mikania glomerata in bitches´s surgical analgesia

Natanni Cinthia Vitor Da Rocha,Marcia Kikuyo Notomi,Yane Fernandes Moreira,Pierre Barnabé Escodro,Diogo Alexandre Tenório Mata,Jackellyne Laís Ferreira Lins,Amanda Caroline Gomes Graboschii,Mylena Ferreira Rodrigues,Ticiano Gomes Do Nascimento

doi:10.33448/rsd-v9i10.8733

Natanni Cinthia Vitor Da Rocha, Marcia Kikuyo Notomi + Show 7 more

Open Access

https://doi.org/10.33448/rsd-v9i10.8733

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Abstract

The aim of this research was to evaluate the analgesia provided by red propolis and Mikania glomerata oral administration in 40 female dogs submitted to ovariohysterectomy (OH) compared to standard treatment with no steroidal anti-inflammatory ketoprofen. Through of a doble-blind and randomized study, the animals were divided in four different groups with 10 animals of treatments: control treatment with ketofen (CT), propolis treatment (PT), Mikania glomerata treatment (MT), and propolis-Mikania glomerata treatment (PGT). All pacients received one of these treatments two hours before OH and the pain evaluation was performed 1 (T1), 6 (T6), 12 (T12), and 24 hours (T24) after OH using University of Melbourne Pain Scale and the Glasgow Composite Measure Pain Scale. Glucose levels were also measured at the same times, except at 6 hours after OH (T6). All treatments achieved similar and satisfactory analgesia. During the experiment, only three animals were rescued, two belonging to the PT and another of the MT. Considering the lower rate of complications and no rescue necessity of in PGT and CT treatments, they were considered the most effective and safer. The combined treatment with propolis and Mikania glomerata could be a promising alternative method for OH surgery analgesia in bitches.

Highlights

In the last decade, the pain measurement and control in pets has been the subject of increasing concern and more researches due the improvement of pain pathophysiology scientific understanding and the relationship between pets and their owners
The aim of this research was to evaluate the analgesia provided by red propolis and Mikania glomerata oral administration in 40 female dogs submitted to ovariohysterectomy (OH) compared to standard treatment with no steroidal anti-inflammatory ketoprofen
Through of a doble-blind and randomized study, the animals were divided in four different groups with 10 animals of treatments: control treatment with ketofen (CT), propolis treatment (PT), Mikania glomerata treatment (MT), and propolis-Mikania glomerata treatment (PGT)

Summary

Introduction

The pain measurement and control in pets has been the subject of increasing concern and more researches due the improvement of pain pathophysiology scientific understanding and the relationship between pets and their owners. The efficacy of analgesic drugs is frequently investigated for use in the pet veterinary market, and many of non-steroidal anti-inflammatory drugs have been indicated for use in bitches submitted to OH, including ketoprofen, vedaprofen, meloxicam, and dipyrone (Selmi et al, 2009; Morgaz et al, 2013; Zanuzzo et al, 2015). The use of natural products as analgesics is still relatively little exploredr. This is especially surprising considering that many potential natural products are of national and regional importance to Brazil, such as Mikania glomerata and red propolis from Alagoas, a protected and endemic species of this region designated recently by the National Institute of Industrial Property (INPI) (under registration number IG201101) (INPI – Brazil, 2012)

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