Abstract
Review question/objective The objective of this review is to identify and synthesize the best available evidence related to the benefits of prone ventilation in critically ill adult patients with Acute Respiratory Distress Syndrome. More specifically, the objectives are to identify: the effectiveness of prone positioning in critically ill adult patients requiring mechanical ventilation due to Acute Respiratory Distress Syndrome on mortality, oxygenation and duration of mechanical ventilation. Inclusion criteria Types of participants This review will consider studies that include patients older than 18 years, regardless of gender or ethnicity, who are critically ill, admitted to ICU for Acute Lung Injury or Acute Respiratory Distress Syndrome as defined by European-American Consensus4 and have failed conventional modes of ventilation. Studies with control group who did not receive tidal volume of 6-8 mL/Kg IDBW ventilation as per ARDS protocol will be excluded. Types of intervention(s)/phenomena of interest This review will consider as the intervention of interest, the mechanical ventilation in prone position as compared with the mechanical ventilation in supine position. Types of outcomes The primary outcome of interest is reported mortality. The secondary outcomes of interest are: improvement in oxygenation measured as ratio of arterial partial pressure of oxygen over fraction of inhaled oxygen (PaO2/FiO2); duration of mechanical ventilation measured as number of days that the patient required mechanical ventilation until discharge from the hospital.
Published Version
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