Abstract
Background: Different treatment regimens of analgesia, nerve blocks and epidurals are used for pain relief in Total Knee Arthroplasty (TKA). Local infiltration analgesia (LIA) is one of the modalities in which a cocktail combination of different medicines is infiltrated locally into the capsule, surrounding tissues or intraarticular joint space. This study aims to analyze the effectiveness of periarticular injection of combination drugs (Bupivacaine, Ketorolac and Morphine) during TKA for postoperative pain management.
 Methods: Total of 150 patients who underwent primary unilateral TKA were randomly categorized into 2 groups (75 each). Group A (control group) didn’t receive intraoperative periarticular injection but Group-B received the intraoperative injection of combined local analgesics and anaesthetics (Bupivacaine, Ketorolac and Morphine). Pain following surgery at 0, 1, and 2 postoperative days were recorded with visual analogue scale (VAS) whereas Knee Society Score was used to evaluate the pain and function pre-operative and 3 months’ post-operative. Statistical analysis was done using SPSS software.
 Results: Patients receiving periarticular infiltration of combination drugs intraoperatively had lower VAS for postoperative pain (p < 0.001) and this group also showed reduced need of analgesia postoperatively.
 Conclusions: Periarticular infiltration of knee during Total Knee Arthroplasty is effective in management of postoperative pain
 Keywords: Periarticular; Total Knee Arthroplasty; combination drugs; postoperative pain
Highlights
The fear of post-operative pain in an elective procedure like Total Knee Arthroplasty (TKA) remains a big concern to patients making it an underused surgery.[1]
The role of adequate analgesia and anesthesia during primary TKA is discussed in literature[3] and different treatment regimens of analgesia, nerve blocks, and epidurals are mentioned.[4,5]
This study aims to analyze the effectiveness of periarticular injection of combination drugs (Bupivacaine, Ketorolac, and Morphine) during TKA for postoperative pain management
Summary
The fear of post-operative pain in an elective procedure like Total Knee Arthroplasty (TKA) remains a big concern to patients making it an underused surgery.[1]. Though epidural analgesia has proven benefits, its multiple side effects make it a little risky choice.[6,7,8] the use of local combinations of analgesics at the surgical site with minimum side effects is a good choice.[9] This study aims to analyze the effectiveness of periarticular injection of combination drugs (Bupivacaine, Ketorolac, and Morphine) during TKA for postoperative pain management. This study aims to analyze the effectiveness of periarticular injection of combination drugs (Bupivacaine, Ketorolac, and Morphine) during TKA for postoperative pain management
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call