Effectiveness of methanol extract hydroid aglaophenia cupressina lamoureoux as antimicrobial in resistant Methicilline Staphylococcus Aureus (MRSA), Shigella sp., Malassezia furfur, and Candida albicans

Abstract

Currently there are many studies that utilize potential of marine resources, because there are many potential bioactive compounds to be developed, especially to overcome multi-drug resistant (MDR) against antibiotics. Hydroid Aglaophenia cupressina Lamoureoux is a marine invertebrate that is often found around spermonde waters containing bioactive compounds that can be developed as a basic ingredient in medicine. This study aims to determine the effectiveness of methanol extract from the Aglaophenia cupessina L. hydroid in inhibiting the growth of Shigella sp. Sd 1617 bacteria, Methicillin-Resistant Staphylococus aureus (MRSA) ATCC 25923 and Malassezia furfur fungi ATCC 14521, and Candida albicans ATCC 10231. In this study, the bioactivity test of methanol extract was carried out by swab method on NA and PDA medium. The concentration of methanol extract used is 5%, 10%, 20% and 40%. Data obtained from measurements of inhibition zone diameter during the incubation period of 24 hours to 48 hours in the Shigella sp. and Methicillin-Resistant Staphylococus aureus (MRSA). While for the Malassezia furfur and Candida albicans fungi incubated for 48 hours to 72 hours. Data obtained in descriptive analysis. The results showed that methanol extract from Aglaophenia cupressina L. hydroid has potential as an antimicrobial which is bactericidal at all test concentrations against the bacterium Shigella sp., Methicillin-Resistant Staphylococus aureus (MRSA) is bacteriostatic (5%, 10%, 40%), bactericidal at a concentration of 20%. Against the fungi Malassezia furfur showed fungistatic properties in all variations in extract concentration, and against Candida albicans was fungicidal at concentrations of 5% and 10%, while concentrations of 20% and 40% were fungistatic.