Abstract
Review question/objective What is the effectiveness of high-intensity interval training for the improvement of cardiorespiratory fitness and other measures of cardiovascular function in patients with coronary heart disease? Inclusion criteria Types of participants This review will consider studies that include male and female adults, of all ages, diagnosed with a condition meeting International Classification of Diseases (ICD-10,WHO 2010) I20-I25 classification of ischemic heart disease including coronary heart disease (atherosclerotic heart disease), myocardial infarction, angina pectoris and ischemic cardiomyopathy. Patients who have undergone recent revascularization procedures (coronary artery stenting, coronary artery bypass grafting or percutaneous transluminal coronary angioplasty) will also be included. Studies of patients with heart failure, following valve surgery, following heart transplantation, or patients with implantable defibrillators will be excluded from this review. Types of intervention(s)/phenomena of interest This review will consider studies that evaluate exercise programs, between four and 12 weeks in duration, consisting of INT, characterized by brief, intermittent bursts of high-intensity exercise (typically 80-95% HR peak ), interspersed by periods of rest or low-intensity exercise. Exercise programs consisting of outpatient, inpatient, community or home-based exercise, will be included for review. The exercise program may stand alone or form a part of comprehensive cardiac rehabilitation. For the purposes of this review, INT will be compared to traditional aerobic exercise training characterized by at least 30 minutes of rhythmic aerobic exercise, such as cycling, walking, running or swimming, performed at a moderate-intensity that is sustainable for the duration of the session (60-70% HR peak ). Types of outcomes The primary outcomes of interest are measures of cardiac and total mortality, as well as cardiac events characterized by hospital admission. Cardiorespiratory fitness, namely peak oxygen consumption (VO 2peak ) will be used as a surrogate measure of cardiovascular health. Other secondary outcomes relating to cardiovascular health, including systolic blood pressure, endothelial function assessed by flow-mediated dilation, and echocardiographically determined cardiac function will be considered.
Published Version
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