Abstract
Wound healing is a well-coordinated process that restores skin integrity upon injury. However, some wound treatment poses harmful effects on the skin, which delay the normal wound healing process. Marphysa moribidii, a marine baitworm or polychaete, represents unique ability to regenerate posterior segment after injury, which may be beneficial in the wound healing treatment. The effectiveness of the polychaete as wound healing treatment was discovered through skin irritation, microbial testing, animal wound model, and chemical identifications. Three polychaete extracts (PE) emulsifying ointment (0.1%, 0.5%, and 1.0%) were topically applied to the full thickness wound model once daily for 14 days. Interestingly, PE 1.0% revealed the most rapid wound healing effects as compared to other treatments, including gamat (sea cucumber) oil (15% w/v) and acriflavine (0.1% w/v). Histopathological analysis using Masson's trichrome staining further confirms that PE treated wound exhibited minimal scar, high collagen deposition, and the emergence of neovascularisation. The extract also displayed a minimum inhibitory concentration (MIC) of 0.4 g/ml against Escherichia coli and absence of skin irritation, infectious bacteria, and heavy metals from the extract. Moreover, chemical compounds such as alkaloid, flavonoid, amino acids, and organic acid were detected in M. moribidii extracts, which could contribute to wound healing activity. In conclusion, this study further justifies the beneficial use of polychaete in treating wound healing and could be developed as a novel bioactive agent in nutraceuticals and pharmaceutical drugs.
Highlights
Skin acts as physical barriers protecting and sealing the body from the external environment and pathogenic substances
Due to overexploitation of gamat as successful traditional wound medicine in Southeast Asia, the gamat’s population is declining over the years, and a number of gamat species have been listed as threatened with extinction by the International Union for Conservation of Nature (IUCN) Red List. erefore, the increasing financial burden, drawbacks, and depletion in the current treatment urges the development of wound remedy from new resources that posed effective healing, yet are more cost-effective, safe, and user-friendly. us, the present study aims to discover the potential of marine worm M. moribidii as an alternative wound healing medicine
At least five animals were used for each treatment (n 5). ere were altogether seven groups of treatment that were tested on Sprague Dawley (SD) rats, namely, three concentrations of aqueous emulsifying ointment of M. moribidii polychaete extract (PE; w/w) (PE 0.1%, PE 0.5%, and PE 1.0%), two positive controls of commercialized wound healing products (w/v) (15.0% gamat oil (PCG)) and 1.0% acriflavine (PCA), and two negative controls (cetomacrogol emulsifying ointment (NC) and no treatment applied (NO) as the untreated group)
Summary
Skin acts as physical barriers protecting and sealing the body from the external environment and pathogenic substances Once this first line of defence is broken, a wound is created, which can cause inflammation and bacterial infections on the intact skin. A wound can be divided into acute and chronic, which much rely on treatment and management. An acute wound may develop into a chronic wound if the healing process fails to progress in time. [4], the development of natural materials as potential therapeutic drugs will be useful for effective wound healing remedies with low cost and less adverse events. Erefore, the increasing financial burden, drawbacks, and depletion in the current treatment urges the development of wound remedy from new resources that posed effective healing, yet are more cost-effective, safe, and user-friendly. Due to overexploitation of gamat (sea cucumber; Holothuroidea) as successful traditional wound medicine in Southeast Asia, the gamat’s population is declining over the years, and a number of gamat species have been listed as threatened with extinction by the International Union for Conservation of Nature (IUCN) Red List. erefore, the increasing financial burden, drawbacks, and depletion in the current treatment urges the development of wound remedy from new resources that posed effective healing, yet are more cost-effective, safe, and user-friendly. us, the present study aims to discover the potential of marine worm M. moribidii as an alternative wound healing medicine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Evidence-based complementary and alternative medicine : eCAM
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
