Abstract
Gel immobilised living cell systems represent a special form of heterogeneous catalysis. Due to mass transfer limitations on substrate delivery and product removal, time-dependent spatial variations in growth rate and biomass densities are created. A dynamic mathematical model has been developed which was used to simulate the start-up dynamics of growing yeast cells in calcium alginate beads. By coupling the transient model with the effectiveness factor calculation, the “dynamic effectiveness factor” could be calculated. The influence of the bead radius and the initial biomass concentration on the dynamic effectiveness factor have been investigated.
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