Abstract
Cryolipolysis is the noninvasive treatment of localized fat through cold-induced panniculitis. The purpose of the present study was to evaluate the safety and efficacy of contrast cryolipolysis for subcutaneous-fat reduction. Contrast cryolipolysis mixes the principles of conventional cryolipolysis and periods of heating in accordance with the contrast lipocryolysis process. Twenty-one subjects aged 34 ± 9 years were treated with contrast cryolipolysis in the regions of abdomen and flanks through the Polarys® device. Anthropometry, standardized photographs, measurements with a skinfold caliper, and diagnostic ultrasounds were performed at the baseline and during follow-ups at 30, 60, and 90 days after the treatment. The safety assessments included laboratory testing and monitoring of the adverse events. The level of significance for all tests was set at P < 0.05. No significant differences in weight and body mass index were found. The waist measurements at the baseline and 30-day follow-up had significant differences, as did the measurements at the 30-day and 60-day follow-ups. The skinfold and ultrasound measurements were significantly reduced in the treated areas in all the time points compared to the baseline. The laboratory results showed no significant changes from baseline. Temporary adverse effects were resolved spontaneously. This study confirmed that contrast cryolipolysis is safe and effective in reducing the fat layer and improving body contouring.
Highlights
Localized adiposity is an abnormal accumulation of fat in usual anatomical locations, and it is an important unaesthetic condition [1]
Liposuction has always been considered the standard treatment for body contouring; because of the potential complications associated with this procedure, new treatments were developed [2, 3]
The subject inclusion criteria were the presence of localized subcutaneous fat in the abdominal and flank regions and a body mass index (BMI) < 30
Summary
Localized adiposity is an abnormal accumulation of fat in usual anatomical locations, and it is an important unaesthetic condition [1]. Liposuction has always been considered the standard treatment for body contouring; because of the potential complications associated with this procedure, new treatments were developed [2, 3]. Several treatments—including ultrasound, radiofrequency, and mesotherapy—have been developed to achieve adipocyte destruction [4,5,6,7,8,9]. A new technology for the noninvasive treatment of localized fat through cold-induced panniculitis—called cryolipolysis—appeared. This method is based on the concept that lipid-rich tissues are more susceptible to injury through cold than the surrounding water-rich tissue is [10]. Studies [11,12,13] have shown that, when alternating low temperatures and cycles of heating, the lipids in the adipocytes crystallize more which is similar to what happens in the tempering
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