Abstract
Objectives: To investigate the effectiveness and outcomes of endoscopic sinus surgery (ESS) in patients with nasal polyps. Methods: A thorough search was conducted for pertinent literature using PubMed, SCOPUS, Web of Science, Science Direct, and Wiley Library. Rayyan QRCI was used throughout this extensive procedure. Results: Our results included nine studies with a total of 780 patients, and 490 (62.8%) were males. The follow-up duration ranged from 4 months to 24 months. All of the included patients underwent ESS for chronic sinusitis with nasal polyps (CRSwNP). Patients with CRSwNP and refractory CRSwNP reported better self-evaluated olfactory function after using ESS, experienced a higher reduction in polyp load, and better quality of life. Conclusion: Patients with CRSwNP reported significant improvements in quality of life and major symptoms when using ESS. The quality of the available data, as established in this evaluation, is low enough to make firm recommendations for the best course of surgical therapy. From a precision medicine perspective, high-quality studies are needed to phenotype these patients in order to identify which ones will benefit most from each type of medicinal and surgical therapy, including a combination of both, with long-term efficiency being a crucial result.
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