Abstract
The study aims to evaluate the radiation safety conditions by detecting the patient's urine excretion rate, calculating the effective half-life, and determining the retention of 177Lu-PSMA in the body. Urine samples of patients were collected for 24hours (6, 12, 18, and 24hours) following the infusion, excretion rate and retention of 177Lu-PSMA in the body of patients were calculated. The measurements of dose rate were performed. Effective half-life calculated from dose rate measurements was found as 18.5±11h within the first 24h and 48.1±22.8h between 24 and 72h. Excreted activity in urine was found as 33.8±20.7, 40.4±20.3, 46.1±22.4, and 53.3±21.5% of total doses at 6, 12, 18, and 24h after administration, respectively. External dose rates for 4h and 24h were 24.51μSv/h, 16.14μSv/h, respectively. Our results showed that 177Lu-PSMA treatment was suitable for outpatient treatment in terms of radiation safety.
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