Abstract
Abstract Background: The emergence of strains of Escherichia coli (E. coli) that are resistant to fluoroquinolones (FQ) has resulted in an increase in infectious complications associated with transrectal ultrasound-guided prostate biopsy (TRUSPB). Two strategies have been proposed to deal with the increase: broadening the antimicrobial coverage and individualizing prophylaxis using transrectal swab cultures. This article describes an alternative strategy, one that adjusts TRUSPB prophylaxis, using the local antibiogram as a guide. Methods: In 2012, screening software for electronic medical records facilitated the identification of seven patients who presented with sepsis within 10 days of a TRUSPB at the Bruce W. Carter Department of Veterans Affairs Medical Center in Miami, Florida. At the time, TRUSPB antimicrobial prophylaxis consisted of oral ciprofloxacin and an intramuscular dose of gentamicin. The outbreak of TRUSPB-associated sepsis between January and June 2012 prompted a reassessment of this reg...
Published Version
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