Effective application of integrative approach in treatment of neuroendocrine colon cancer. Clinical case

M M Davydov,D A Chekiny,P A Zeynalovа,A A Filimonov,A A Fedenko,E V Dementievа,E K Ibragimov

doi:10.17650/2782-3202-2022-2-1-28-32

Abstract

Neuroendocrine tumors are rare type of tumors of the gastrointestinal tract. Mostly the patient is diagnosed rather late, the tumors don’t have specific symptoms and there are no sensitive and specific methods of early diagnostics of the disease. Also, to date, the choice of antitumor treatment methods is limited. The article presents a clinical case of effective treatment of a neuroendocrine tumor of the colon with high level of microsatellite instability. After palliative partial colectomy, atypical resection of the liver, female patient with metastatic cancer of the descending colon has been receiving therapy with checkpoint inhibitors (PD-1) which led to long-term stabilization of the process.

Highlights

Neuroendocrine tumors are rare type of tumors of the gastrointestinal tract
The article presents a clinical case of effective treatment of a neuroendocrine tumor of the colon with high level of microsatellite instability
Atypical resection of the liver, female patient with metastatic cancer of the descending colon has been receiving therapy with checkpoint inhibitors (PD-1) which led to long-term stabilization of the process

Summary

Introduction

Neuroendocrine tumors are rare type of tumors of the gastrointestinal tract. Mostly the patient is diagnosed rather late, the tumors don’t have specific symptoms and there are no sensitive and specific methods of early diagnostics of the disease. The article presents a clinical case of effective treatment of a neuroendocrine tumor of the colon with high level of microsatellite instability. Atypical resection of the liver, female patient with metastatic cancer of the descending colon has been receiving therapy with checkpoint inhibitors (PD-1) which led to long-term stabilization of the process.

Results

Conclusion