Abstract
A quantitative determination of the pharmacological effect of the prostaglandin analogue 16-phenoxy- ω-17,18,19,20-tetranor-PGE 2 methyl sulfonylamide (16-phenoxy- PGE 2) and the natural prostaglandin E 2 has been made vivo upon the human myometrium during early pregnancy. The method for the investigation, hysteronetry, is based upon the concept that mechanical distension of smooth muscle induces contraction. The contractile response was recorded under basic conditions and during intravenous infusion of the active agent. It was found that the analogue had a ‘potency’ similar to or slightly more pronounced than the natural E 2 when the comparison was made on a microgram basis.
Published Version
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