Abstract
Expression of human p53 carrying missense mutations at codons 175 (His175), 194 (His194), 248 (Trp248), and 273 (His273) has different effects on sensitivity of K562, 10(1), 10(3), and Rat1 cells to the antitumor drugs methotrexate, etoposide, vinblastine. These effects of mutant p53 depend on both particular amino acid substitution and cell context (histogenetic type, status of the second allele,etc.)
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