Abstract
The effect of intraperitoneal (70 mg/kg) and local (39 μg) injections of β-phenylethylamine (βPEA) on evoked potentials (EP) in the caudate nucleus during stimulation of the compact zone of the substantia nigra in the frontal cortex was investigated in rats. For local application of βPEA, glutamate, and haloperidol a push-pull cannula system with simultaneous recording of EP was used. Definite specificity in the action of the drugs on EP of cortical and nigral origin was found. Intraperitoneal injection of βPEA caused a faster and stronger decrease in amplitude of the N2−P2 component in the response to stimulation of the substantia nigra than local application, but had very little effect on the amplitude of EP in response to stimulation of the frontal cortex. It was shown by the use of haloperidol that the N2−P2 component of EP in response to stimulation of substantia nigra is dopaminergic in nature. It is suggested that endogenous βPEA may be a regulator of the function of dopaminergic neurons in the nigro-neostriatal system of the rat brain.
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