Abstract
This study was designed to determine the effect ofCarica papayaL. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed thatC. papayaL. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded thatC. papayaL. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.
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