Effect of zinc toxicity on the blood parameters of the laboratory mice

Abstract

The present search conducted at thecollegeofVeterinary Medicine–Universityof Basrahto investigate the effect of zinc toxicity on the physiological parameters, histopathological changes and reproductive efficiency in the laboratory mice. In this search, 32 mice were used, they were divided into two groups, each one consisted of four equal subgroups with 4 mice in each. The first three subgroups of each group were dosed via intraperitoneal injection with 60, 80 and 100 mg/kg zinc in the form of ZnSO4 for 15 and 30 days. An equivalent volume of saline (0.9 %N.S) was administered to the fourth subgroup which was set as the control group. The investigation of blood parameters included RBC count, Hb concentration, PCV concentration, total and differential WBC count. The results here showed a significant decrease (P≤0.05) of RBC count, Hb concentration, PCV value, and neutrophil count, whereas there was a significant increase (P≤0.05) of total WBC count, lymphocyte count, monocyte count, and there were no significant differences in the acidophil count and basophil count.