Abstract

Background: Type 2 diabetes mellitus is a progressive condition in which the body becomes resistant to the normal effects of insulin and/or gradually loses the capacity to produce enough insulin the pancreas. Objectives: This case-control study was conducted to assess the effect of vitamin E on oxidative stress indicated by malondialdehyde and paronxanase 1 level on T2DM patients with retinopathy. Patients and Methods: Two equal groups each consisted of thirty patients; the 1st group was T2DM without retinopathy (control) and the 2nd one was T2DM with retinopathy (case). Results: There was statistically significant positive correlation Oppositely, paroxanase 1 level was statistically significantly negatively correlated with hydroperoxidase. As. Also, there was statistically significant increase on paroxanase 1 level after 3-month vitamin E application as an antioxidant among the T2DM with retinopathy group. Conclusion: Serum MDA levels were associated with DR stage, suggesting that oxidative stress play a significant role in DR progression. On the other hand, MDA levels were reduced and proliferative DR patients after vitamin E intake for 3 months.

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