Abstract
Various studies reported the relationship between Helicobacter pylori (Hpylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta-analysis to clarify the relationship between vitamin D and Hpylori infection, and vitamin D and Hpylori eradication. Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English-language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Ten articles were finally included. It was demonstrated that average 25(OH)D level in Hpylori-positive patients was lower than Hpylori-negative (SMD = -0.53ng/mL, 95% CI = (-0.91, -0.16ng/mL)). For Hpylori eradication individuals, the result showed that average 25(OH)D level in Hpylori successful eradication individuals was higher than unsuccessful (SMD=1.31ng/mL, 95% CI=[0.60, 2.02ng/mL]). In addition, individuals with vitamin D deficiency had lower Hpylori eradicate rate (OR=0.09, 95% CI=[0.02, 0.41]). Sensitivity analysis showed that the meta-analysis results were stable and reliable. Vitamin D was a protective factor to Hpylori infection. Moreover, vitamin D can improve the success rate of Hpylori eradication.
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