Abstract
BackgroundStudies have shown diverse results regarding the association between H. pylori (HP) infection and the risk of malignancy. There is accumulating evidence relating HP infection to urological diseases. We investigated whether there was an association between HP-infected peptic ulcers and the subsequent risk of prostate cancer.MethodsWe collected HP-infected male patients from 1998 to 2008 from the Longitudinal Health Insurance Database (LHID). HP-infected patients were identified as those who had a diagnosis of peptic ulcers upon admission and received HP eradication therapy within 1 year after diagnosis. The date of HP infection diagnosis upon admission was defined as the index date. Patients aged < 20 years or with a cancer history were excluded. For each HP-infected patient, we selected four males without peptic ulcers or a history of HP eradication in the LHID for the comparison cohort according to propensity score matching by age, index year, and comorbidity. The risk of prostate cancer and associated risk factors was assessed by Cox proportional hazard regression.ResultsA total of 2620 HP infection treatment patients and 10,480 matched comparisons were selected. There were 36 patients in the HP-infected treatment cohort and 117 patients in the comparison cohort with documented prostate cancer development (1.52 and 1.21 per 1000 person-years, respectively). Compared to the comparison cohort, the HP infection cohort had a 1.26-fold increased prostate cancer risk in the Cox models after adjusting for matched-pairs (95% CI = 0.87–1.34). There were no significant differences in subsequent prostate cancer development between HP-infected treatment patients and the comparison cohort.ConclusionOur findings showed no significant association between HP-infected peptic ulcers and the subsequent risk of prostate cancer. Further studies are warranted to investigate whether this observation is attributable to an HP eradication policy.
Highlights
Studies have shown diverse results regarding the association between H. pylori (HP) infection and the risk of malignancy
HP infection can often be found in most peptic ulcer patients, and eradication of HP has been associated with good outcomes [2]
Studies have shown that HP infection is associated with decreased risks of esophageal adenocarcinoma and esophageal squamous cell carcinoma in Eastern populations
Summary
Studies have shown diverse results regarding the association between H. pylori (HP) infection and the risk of malignancy. We investigated whether there was an association between HP-infected peptic ulcers and the subsequent risk of prostate cancer. There is a close association between Helicobacter pylori (HP) infection and peptic ulcer disease [1]. An inverse relationship has been shown between HP infection and gastric cardia cancer [11, 12]. These results indicate that HP infection might play different roles in the development of various malignancies
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